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Posted on: May 29, 2019 at 18:09:41 CT

Our analysis strongly suggests that pre-fertilization activity of the drug could, in a routine clinical setting, prevent less than 15 percent of expected conceptions. The drug has minimal effects on cervical mucus or sperm functions and has limited ability to prevent ovulation on the most fertile days of the cycle. However, pre-ovulatory drug administration can lead to post-fertilization luteal effects (such as lowered progesterone, LH, glycodelin levels, shortened luteal phase, and altered endometrial histology) and may explain its clinical efficacy when used before ovulation.

In conclusion, LNG-EC administration during the pre-ovulatory days, the most fertile in the cycle, cannot prevent ovulation or fertilization with a dominant pre-fertilization MOA, but can be demonstrated to impair luteal function and may adversely affect the survival of the embryo.

This information should be made available to users of LNG-EC so that they can make their choice based on informed consent.