The null hypothesis is "Treatment A does not work"
You then do the study to disprove it.
But I'll be gracious tonight. I haven't found a prospective, randomized, double blind study on all three medications (there are a few in the Clintrials website that are presumably still being conducted without results)
Here's one with HQN+Az
https://www.nejm.org/doi/full/10.1056/nejmoa2019014
HQN alone
https://jamanetwork.com/journals/jama/fullarticle/2772922
HQN alone
https://www.nejm.org/doi/full/10.1056/nejmoa2023184
(note: See also how remdesivir did not do well either)
Email Zelenko and ask him to publish a trial.